Chromosome, a substance to pass our genome from mother to daughter cells, is highly organized structure that is changed dynamically under the regulation of cell cycle. To divide the genome successfully into two daughters, chromosomes, in the first place, must establish sister-chromatid cohesion during DNA replication. Next, in mitosis, chromosomes must be packed into a micrometer-sized spindle apparatus, which captures chromosomes in a bipolar fashion. How does chromosome achieve those events towards successful segregation? And how is the chromosome structure organized to support chromosomal functions? To answer these questions, we address the following projects by using cell biological and biochemical methods.
・How is the genome equally divided into two daughter cells?
・Unveiling the chromosome structure in single-molecule resolution.
・Evolution of chromosome structure.
・Chromosomal regulators and hereditary disorders.